Smallholder farmers in Afghanistan are already facing various risks in agricultural production due to past continuous insurgencies. Climate change is likely to amplify the risk and make them even more vulnerable. The present study attempted to evaluate the vulnerability profiles of smallholder farmers due to climate change using the IPCC Framework. Primary data on relevant parameters for assessing climate change-led social vulnerability in the region were collected by classifying study region into two zones: the plain and the hills of Yangi Qala District in Takhar province, Afghanistan. Thirteen villages from each zone were selected at random, and face-to-face interviews were conducted with ten randomly selected households in each of the selected villages in both zones based on a pre-tested questionnaire. The questionnaire contained indicators for all three dimensions of vulnerability: exposure, sensitivity and adaptive capacity. The collected data were subjected to a proposed vulnerability index, after estimating the indices of the three dimensions of vulnerability.